Journal: Frontiers in Physiology
Article Title: Dexmedetomidine Exerted Anti-arrhythmic Effects in Rat With Ischemic Cardiomyopathy via Upregulation of Connexin 43 and Reduction of Fibrosis and Inflammation
doi: 10.3389/fphys.2020.00033
Figure Lengend Snippet: (A) Typical M-mode echocardiograms from sham-operated rats (Sham) and rats with 4-week ligated LAD (ICM) and changes in LVESd, LVEDd, LVEF, and LVFS between Sham group and ICM group. (B) ECG parameters obtained from six groups after 4-week pharmacological treatment. Thin and akinetic anterior wall (AW), hypokinetic posterior wall (PW), and dilated cardiac cavity were detected in rats with ICM. A 4-week treatment of Dex lowered the heart rate in ICM rats, while the Sham group and ICM group shared similar heat rates. ICM rats had longer QTc than did Sham rats, and Dex inhibited the effect of ischemia on the prolongation of QTc. BML had no effects on ECG parameters. Data are expressed as mean ± SD. * p < 0.05 vs. Sham group, # p < 0.05 vs. ICM group ( n = 8 for each group).
Article Snippet: The digitized one-channel ECG signals were captured and analyzed by LabChart Pro ECG Analysis Module (ADInstruments, United States).
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